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 counterfactual inference



A Related Work

Neural Information Processing Systems

For instance, one such notion is'unawareness', which necessitates Additionally, preference-based fairness argues that an algorithm's design should not be solely determined by its creators or regulators but should also incorporate the preferences of those directly A myriad of techniques exist to construct fair models using counterfactual inference. Theorem 2. Assume that R has been generated using Algorithm 2. We have, Pr(R We consider a causal graph shown in Figure 6. The counterfactual data ˇ X were computed by substituting A in the structural function with ˇ A . We implemented our method and the baseline methods as described in Section 5 (since there is no difference between observed data and factual data in this scenario, we have no ICA baseline here). For the CR method, we set the weight of the fairness regularization term as 0.05.


Integrating Markov processes with structural causal modeling enables counterfactual inference in complex systems

Neural Information Processing Systems

This manuscript contributes a general and practical framework for casting a Markov process model of a system at equilibrium as a structural causal model, and carrying out counterfactual inference. Markov processes mathematically describe the mechanisms in the system, and predict the system's equilibrium behavior upon intervention, but do not support counterfactual inference. In contrast, structural causal models support counterfactual inference, but do not identify the mechanisms.


Mitigating Gender Bias in Depression Detection via Counterfactual Inference

Hu, Mingxuan, Ma, Hongbo, Wu, Xinlan, Liu, Ziqi, Liu, Jiaqi, Chen, Yangbin

arXiv.org Artificial Intelligence

Audio-based depression detection models have demonstrated promising performance but often suffer from gender bias due to imbalanced training data. Epidemiological statistics show a higher prevalence of depression in females, leading models to learn spurious correlations between gender and depression. Consequently, models tend to over-diagnose female patients while underperforming on male patients, raising significant fairness concerns. To address this, we propose a novel Counterfactual Debiasing Framework grounded in causal inference. We construct a causal graph to model the decision-making process and identify gender bias as the direct causal effect of gender on the prediction. During inference, we employ counterfactual inference to estimate and subtract this direct effect, ensuring the model relies primarily on authentic acoustic pathological features. Extensive experiments on the DAIC-WOZ dataset using two advanced acoustic backbones demonstrate that our framework not only significantly reduces gender bias but also improves overall detection performance compared to existing debiasing strategies.


Synthetic Counterfactual Labels for Efficient Conformal Counterfactual Inference

Farzaneh, Amirmohammad, Zecchin, Matteo, Simeone, Osvaldo

arXiv.org Artificial Intelligence

This work addresses the problem of constructing reliable prediction intervals for individual counterfactual outcomes. Existing conformal counterfactual inference (CCI) methods provide marginal coverage guarantees but often produce overly conservative intervals, particularly under treatment imbalance when counterfactual samples are scarce. We introduce synthetic data-powered CCI (SP-CCI), a new framework that augments the calibration set with synthetic counterfactual labels generated by a pre-trained counterfactual model. To ensure validity, SP-CCI incorporates synthetic samples into a conformal calibration procedure based on risk-controlling prediction sets (RCPS) with a debiasing step informed by prediction-powered inference (PPI). We prove that SP-CCI achieves tighter prediction intervals while preserving marginal coverage, with theoretical guarantees under both exact and approximate importance weighting. Empirical results on different datasets confirm that SP-CCI consistently reduces interval width compared to standard CCI across all settings.



Cyclic Counterfactuals under Shift-Scale Interventions

Saha, Saptarshi, Rathore, Dhruv Vansraj, Garain, Utpal

arXiv.org Machine Learning

Most counterfactual inference frameworks traditionally assume acyclic structural causal models (SCMs), i.e. directed acyclic graphs (DAGs). However, many real-world systems (e.g. biological systems) contain feedback loops or cyclic dependencies that violate acyclicity. In this work, we study counterfactual inference in cyclic SCMs under shift-scale interventions, i.e., soft, policy-style changes that rescale and/or shift a variable's mechanism.


A Hybrid Enumeration Framework for Optimal Counterfactual Generation in Post-Acute COVID-19 Heart Failure

Cheng, Jingya, Azhir, Alaleh, Tian, Jiazi, Estiri, Hossein

arXiv.org Artificial Intelligence

Counterfactual inference provides a mathematical framework for reasoning about hypothetical outcomes under alternative interventions, bridging causal reasoning and predictive modeling. We present a counterfactual inference framework for individualized risk estimation and intervention analysis, illustrated through a clinical application to post-acute sequelae of COVID-19 (PASC) among patients with pre-existing heart failure (HF). Using longitudinal diagnosis, laboratory, and medication data from a large health-system cohort, we integrate regularized predictive modeling with counterfactual search to identify actionable pathways to PASC-related HF hospital admissions. The framework combines exact enumeration with optimization-based methods, including the Nearest Instance Counterfactual Explanations (NICE) and Multi-Objective Counterfactuals (MOC) algorithms, to efficiently explore high-dimensional intervention spaces. Applied to more than 2700 individuals with confirmed SARS-CoV-2 infection and prior HF, the model achieved strong discriminative performance (AUROC: 0.88, 95% CI: 0.84-0.91) and generated interpretable, patient-specific counterfactuals that quantify how modifying comorbidity patterns or treatment factors could alter predicted outcomes. This work demonstrates how counterfactual reasoning can be formalized as an optimization problem over predictive functions, offering a rigorous, interpretable, and computationally efficient approach to personalized inference in complex biomedical systems.


A Related Work

Neural Information Processing Systems

For instance, one such notion is'unawareness', which necessitates Additionally, preference-based fairness argues that an algorithm's design should not be solely determined by its creators or regulators but should also incorporate the preferences of those directly A myriad of techniques exist to construct fair models using counterfactual inference. Theorem 2. Assume that R has been generated using Algorithm 2. We have, Pr(R We consider a causal graph shown in Figure 6. The counterfactual data ˇ X were computed by substituting A in the structural function with ˇ A . We implemented our method and the baseline methods as described in Section 5 (since there is no difference between observed data and factual data in this scenario, we have no ICA baseline here). For the CR method, we set the weight of the fairness regularization term as 0.05.